Toxin

Tier List

Villain, City, Bio, Brawler, Spider-Verse, Symbiote, Symbiote Six

Arena	★ ★ ★ ★ ★
Alliance War Offense	★ ★ ★ ★ ★
Alliance War Defense	★ ★ ★ ★ ★
Cosmic Crucible Offense	★ ★ ★ ★ ★
Cosmic Crucible Defense	★ ★ ★ ★ ★
Raid	★ ★ ★ ★ ★
Dark Dimension / Saga	★ ★ ★ ★ ★
Battleworld	★ ★ ★ ★ ★

Iso-8

Toxin is a very fast character, but he doesn’t take the first turn on the team, which makes Striker a strong Iso-8 class choice for him. He can benefit from attacking targets that already have Vulnerable, thanks to Quicksilver (Symbiote), who plays before him and applies Vulnerable with his attacks (he should be Raider). Additionally, since Toxin passively assists all his Symbiote Six allies, in matches where assists aren’t blocked, it can be useful to run him as a Skirmisher, while most of the other team members are Strikers. This creates a powerful Striker-Skirmisher combo.

However, many current meta teams against whom you’ll be using Symbiote Six—whether in Arena, Crucible, or War—often have mechanics that block assists, making Skirmisher less effective in those matchups. Ultimately, the best Iso-8 class for Toxin depends on the situation, but in most cases, Striker will be the preferred choice, or possibly even Raider for extra crit potential. Don’t forget that Toxin can apply Ability Block with his Iso-8 attack to targets with Exposed, making Striker an especially solid option for maximizing his impact.

T4 Priority

P – Passive ability

S – Special ability

B – Basic ability

U – Ultimate ability

Passive – Gains powerful control effects against enemy Mythic characters. Whenever an enemy drops below 50% health or uses their Special Ability, if that character has Exposed and is Mythic, Toxin applies Trauma for 2 turns. Additionally, if Toxin has at least two Symbiote Six allies, then in Arena, enemies with Exposed who normally cannot gain Trauma can now gain it (though this does not bypass Immunity).

This is an excellent upgrade for matchups against Mythic characters, as it allows the Symbiote Six team to apply Trauma even to those who are usually immune (Odin), giving them a strong edge in key Arena battles.

Special – Increased damage and, most importantly, apply Stun for 2 turns to the primary target. This upgrade gives Toxin, and by extension the entire Symbiote Six team, much stronger control over the battlefield, allowing them to lock down key enemies and swing the fight in their favor.

Basic – Deals slightly more damage and applies Ability Block to targets that have Exposed. This effect also carries over to his Iso-8 attacks, so as a Striker, whenever Toxin attacks a target with both Vulnerable and Exposed, he will also apply Ability Block with his follow-up Striker attack. This upgrade significantly boosts Toxin’s control potential, allowing him to reliably shut down enemy abilities and strengthen the overall control the Symbiote Six team brings to a fight.

Additionally, whenever Toxin assists or counterattacks, he will also apply Ability Block to targets with Exposed, since this upgrade affects his Iso-8, Counter Attack, and Assist actions as well. Given that Toxin frequently assists his teammates and can gain Counter through Venom, this makes him a constant threat to shutting down enemy abilities throughout the battle.

Ultimate – Deal increased damage and, if any target has Exposed, he will transfer positive effects (except Taunt) from that target to himself before the attack. This upgrade allows Toxin to buff himself even further right before unleashing his Ultimate, making him more powerful and giving him an extra edge in battle.

Infographics

About Character

Toxin is a fascinating character in the Marvel Universe, known for being one of the most powerful symbiotes. He is the offspring of Carnage and, by extension, a “grandchild” of Venom, making him part of the symbiote family tree that has shaped many pivotal storylines in Marvel comics.

The Toxin symbiote first bonded with NYPD officer Patrick Mulligan, creating a unique dynamic. Unlike many symbiotes that push their hosts toward violence and chaos, Toxin and Mulligan strive to use their combined powers for good. This partnership explores the constant struggle between the symbiote’s primal urges and the host’s moral compass. Toxin’s abilities include superhuman strength, agility, shape-shifting, and the power to generate tendrils and webbing. He also inherits the strengths of both Venom and Carnage, making him exceptionally versatile in combat.

Toxin stands out among symbiotes because he constantly battles his own darker instincts, with his hosts often trying to maintain control and use the symbiote’s powers responsibly. This internal conflict adds depth to his character, as he is neither purely heroic nor entirely villainous. In the Marvel Universe, Toxin represents the potential for redemption among symbiotes and the idea that even those born from chaos can choose their own path.

Toxin is a Brawler and the primary damage dealer of the Symbiote Six team. His kit is built around not only dealing massive damage but also disrupting and controlling opponents through a range of powerful effects. One of Toxin’s signature mechanics is the Exposed debuff, which he passively applies to enemies whenever they fall below 50% Health or use their Special ability. This Exposed status opens up a range of additional effects: for example, when Toxin uses his Basic attack on a target with Exposed, he applies Ability Block, shutting down their key abilities.

Toxin’s Ultimate ability becomes even more potent if the target has Exposed, allowing him to transfer positive effects from the primary or adjacent targets onto himself. Enemies afflicted with Exposed are heavily penalized—they cannot gain Deathproof, Stealth, or Evade, cannot assist their teammates, have reduced Resistance, and in Arena, even those who would normally be immune can receive Trauma.

Toxin is also a strong finisher: any character he defeats cannot be revived, and every time he gets a kill, he passively removes negative effects from himself and fills his Speed Bar, allowing him to stay in the fight and strike again quickly. He further supports his team by gaining Assist Now on every Symbiote Six ally turn, making him a reliable source of extra attacks throughout the battle.

With his Special, Toxin can apply Stun to an opponent, and his Ultimate scales damage based on the number of positive or negative effects on himself. He is also capable of applying Bleed, ensuring sustained pressure on the enemy team. Toxin’s combination of high damage, frequent assists, crowd control, and the ability to cripple or finish off key opponents makes him not only a devastating attacker but also a strategic controller in the Symbiote Six lineup.

You can find detailed information about Toxin on the Symbiote Six team page HERE.

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