Hero Tier List and ISO-8 suggestions

Creating Character Tier List for MSF at the moment is not very helpful. The problem is that every character has its own META value as long as they are in the right teams.

Nevertheless, we made a list of all MSF Heroes and rank them for every game segment. Five Red Stars mean that the character is in the Top Tier while one Red Star represents the lowest Tier.

You can quickly find every character in the game by typing a few letters from their name in the Search field.

Last but not least, we have given suggestions and explanations about ISO-8 classes for every character. Everything you need to do is type the name and you’ll find everything about your Hero or Villain.

Enjoy!

MSF Search

Name
Mister Negative
Spider Weaver
Spider-Man (2099)
Spider-Man [Noir]
Red Hulk
Abomination
Brawn
Hulkbuster
Deathlok
Viv Vision
Rogue
Sunfire
Mighty Thor
Valkyrie
Wong
Star-Lord [T’Challa]
Spider-Punk
Sersi
Scarlet Spider
Morgan Le Fay
Morbius
Magik
Madelyne Pryor
Kate Bishop
Ikaris
Ghost-Spider
Echo
Dormammu
Doctor Voodoo
Doctor Strange [Heartless]
Agatha Harkness
Spider-Woman
Nico Minoru
Gambit
Fantomex
Dazzler
Omega Red
Lady Deathstrike
Silver Samurai
Deathpool
Cloak
Dagger
Shang Chi
Sharon Carter
Maria Hill
Captain America [Sam Wilson]
Adam Warlock
Moondragon
Phyla-Vell
Doctor Doom
Kestrel
Jubilee
Colleen Wing
Misty Knight
Bishop
Ghost
Stature
Yellowjacket
Anti-Venom
Scream
Shatterstar
She-Hulk
Doctor Octopus
Swarm
Electro
Baron Zemo
Beast
Squirrel Girl
Emma Frost
X-23
Yelena Belova
Negasonic
Domino
Ebony Maw
Cull Obsidian
Taskmaster
Corvus Glaive
Proxima Midnight
Red Skull
Jessica Jones
Mister Sinister
Mystique
Juggernaut
Agent Coulson
America Chavez
Ant-Man
Black Bolt
Black Panther
Black Widow
Blob
Bullseye
Cable
Captain America
Captain Marvel
Carnage
Colossus
Crossbones
Crystal
Cyclops
Daredevil
Phoenix
Deadpool
Doctor Strange
Drax
Elektra
Elsa Bloodstone
Falcon
Gamora
Ghost Rider
Graviton
Green Goblin
Groot
Hawkeye
Heimdall
Hela
Hulk
Human Torch
Iceman
Invisible Woman
Iron Fist
Iron Man
Ironheart
Karnak
Killmonger
Kingpin
Kitty Pride
Korath the Pursuer
Loki
Longshot
Luke Cage
Magneto
Mantis
M’Baku
Minn-Erva
Mister Fantastic
Mordo
Moon Knight
Ms.Marvel
Multiple Man
Mysterio
Namor
Nebula
Nick Fury
Night Nurse
Nobu
Okoye
Polaris
Psylocke
Punisher
Pyro
Quake
Red Guardian
Rescue
Rhino
Rocket Raccoon
Ronan the Accuser
Sabretooth
Scarlet Witch
Scientist Supreme
Shocker
Shuri
Silver Surfer
Sif
Spider-Man
Spider-Man [Miles]
Spider-Man [Symbiote]
Star-Lord
Storm
Stryfe
Thanos
The Thing
Thor
Toad
Ultimus
Ultron
Venom
Vision
Vulture
War Machine
Wasp
White Tiger
Winter Soldier
Wolverine
Yondu
Yo-Yo

Mister Negative

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★

Iso-8

Mister Negative's efficiency depends on his ability to land his debuffs and utility. In normal circumstances, it would be only logical to equip him with Skirmisher class. However, since he is in the top 20 characters when we measure Focus, and since he has a passive ability that increases Focus, there is an option to enhance his damage by giving him a Raider class.

The decision should depend on the rest of the Underworld team.

My plan is to give Skirmisher to Mister Negative, the Raider Class to Taskmaster and the Striker to Green Goblin.

Spider Weaver

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Spider Weaver is the first Spider Protector. The amount of her current Health crucially influences her offensive capabilities, so it is important trying to protect her from being injured.
The only logical course of action is to give her the Fortifier ISO-8 class. Additional Barrier is the only way of protecting her Health and it is in synergy with her passive ability to gain Barrier each turn.

A lot of players avoid placing Fortifier on their characters, so if you are one of them you have only 2 options -

  • to increase the damage output of Spider Weaver by giving her the Striker class
  • to try to make sure that she will always land Bleed, Stun, and Trauma by giving her the Skirmisher Class

In my opinion, Spider Weaver is an ideal character for the Fortifier class.

Spider-Man (2099)

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Deciding which ISO-8 class to give Spider-Man (2099) is very tricky.

In Cosmic Crucible, he needs all the critical chance he can get to have an option to prolong debuffs on enemies. He can prolong debuffs with all his active abilities, so giving him the Raider ISO-8 class in CC is the only logical thing to do.

However, outside of Cosmic Crucible, he needs Skirmisher Class without a doubt. It is of utmost importance that he lands all the debuffs at his disposal and flips 1 random buff on all enemies each turn. The only way you can make sure that will happen is to further increase his Focus with the Skirmisher ISO-8 class.

My suggestion is to give him Raider initially but to slowly build him, Skirmisher, as well. When you are done you should change it when needed.

Spider-Man [Noir]

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Spider-Man [Noir] is a pure Blaster damage dealer with a couple of debuffs at his disposal. Those debuffs are not essential for his effectiveness, so it is only logical to improve his damage output through the ISO-8 class.

Depending on the needs of the Tangled Web team, Spider-Man [Noir] should be equipped with the Striker class as a primary option or the Raider class as a secondary option. The decision should be made according to random members of Tangled Web setup and only if there are not enough characters to place Vulnerability, Spider-Man [Noir] should be equipped with the Raider class. In all other options, he should prioritize the Striker class.

Red Hulk

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Red Hulk is a character who will retaliate a lot. Once all of his Charges are Up he will perform a Counterattack every time someone hit him. Having that in mind, it would be logical to equip him with Skirmisher, especially if you want to be sure that his utility from the ultimate and basic attack (flipping positive effects) will always be effective. If you give him Skirmisher he will always flip positive effects with his assists and counterattacks but the main effect of Skirmisher (removing buffs against a target with Vulnerable) will be useless. That is because Red Hulk already has the ability to flip positive effects with every attack.


Your decision for ISO-8 should depend on the strength of your Red Hulk. If you are using him for PVE, he doesn't need Skirmisher - it is better to give him Striker. However, if you are using him in PVP against characters that are considerably stronger in power than him, giving him Skirmisher is the only option to be sure that he will flip positive effects with his attacks.

One thing is certain, once you maximize Red Hulk the only course of action is to give him the Striker Class.

Abomination

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Abomination already has increased Focus. Even though he needs that all of his debuffs and utilities are always placed, giving him the Skirmisher Class may not be necessary.

According to his kit, Abomination is ideal for the Raider class. It is true that his critical chance will be at 100% with his special ability but that only means that he will place Vulnerability on all enemies every time he uses that skill.

Depending on the class of other GAMMA members he could also benefit from the Striker class on some occasions, but keep in mind that the damage from his abilities is not that great - he mainly relies on his utilities.

According to the kit, Abomination should not have a problem placing his utilities and debuffs. However, if that proves to be a false expectation, then Abomination must be equipped with the Skirmisher - he will reach full potential only if he is fully capable to clear Def Ups and place Def Downs.

From our game experience, we strongly suggest having Abomination as Skirmisher. It is so important for him to put all of his debuffs and flip effects with his special/ultimate attacks. At least until you have him on 5 red stars.

Brawn

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Choosing ISO-8 class for Brawn is very simple. You have 2 options.

The first option is to give him the Healer class like the majority of other support characters and to use him only as healing support, regardless of his utilities.

However if you want that Brawn always steals all buff from enemies and spread it to all GAMMA members with his special, then you must give him the Skirmisher ISO-8 class.

In my opinion for AW, he will definitely need Skirmisher to be prioritized.

Hulkbuster

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Bionic Avengers are a unique team in MSF due to their Ability Energy distribution mechanics. Hulkbuster's role besides providing Ability Energy is to generate Barriers for the team.

A Protector who creates Barrier will always benefit from the Fortifier ISO-8 class. This goes for Hulkbuster especially due to his basic attack that buffs him according to the strength of Barrier.

However, Hulkbuster could be equipped with Striker or Skirmisher as well depending on the team's needs. As someone who will always assist Iron Man, it is important that he strikes as hard as possible. Also, in order to make sure that his utility is placed and to exploit his assists with the possible clearing of enemy buffs, he could use Skirmisher as well.

The final decision should depend on the class distribution to other Bionic Avengers.

Deathlok

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Deathlok's basic attack is dependent on his critical chance. Also, his special and ultimate abilities are both AOEs, so it is only natural to equip him with Raider ISO-8 class.

There is a solution to further emphasize his damage by giving him the Striker ISO-8, but if you do so be sure that Vision is equipped with Skirmisher and Iron Man with Raider ISO-8 class.

Viv Vision

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Like all Support Healers, Viv Vision will thrive the most with the Healer ISO-8 class. This goes especially if you are building her for Raids. Honestly, any other class provides far less to the team.

However, if you build Viv Vision and Bionic Avengers to be competitive in WAR or Cosmic Crucible, you might consider giving her Skirmisher class because of two reasons.

First, you want that her Ability Block is placed always, no matter the cost. Second, you need someone in the team to be the Skirmisher class and remove enemy buffs, so you can land your debuffs without a problem. Considering, that most of the Bionic Avengers will benefit the most from the Raider or Striker class, Viv Vision is an ideal pick for the Skirmisher class.

Rogue

Arena★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Rogue is definitely the best Protector in the game currently. As Legendary Protector, she already has increased Focus on placing a wide variety of debuffs at her disposal. However, this goes only for Cosmic Crucible.

Outside of Cosmic Crucible, Rogue should have Skirmisher obviously - you want that her debuffs to land and everything else is less important.

However, in Cosmic Crucible, things are different. Rogue will land all her debuffs always so you must choose another class so she can be fully effective. Fortifier is a natural option for Protector and it will increase Rogues' sustenance significantly. The other option is to give her Striker class so she can exploit Vulnerability with her mighty attacks. The third option is to give her Skirmisher nevertheless and stop thinking about Rogue's class.

If you don't have enough resources you will most likely pick the third option but if you wanna min-maxing stats and utilize all Rogue's strengths you will find time for maximizing another ISO-8 besides Skirmisher (Fortifier or Striker) class and use it accordingly.

Sunfire

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Sunfire is a pure damage dealer who can occasionally place bleed with his basic attack and who can open the combat with Def Down on all enemies. Unfortunately, Sunfire is very slow and while his skill-set suggests otherwise he will start playing only when Dazzler, Rogue, and Gambit have already made their attacks.

Having that in mind it is not mandatory to emphasize Sunfire Focus with Skirmisher class making sure that he will land Def Down on all enemies. Nevertheless, if you don't have someone on the team to place Vulnerability, Sunfire can use Skirmisher without any disadvantages. But if you gave Skirmisher to Rogue, Gambit, or Dazzler (which is the most likely thing to do) it is best to exploit existing Weaknesses on the battlefield by using Striker on Sunfire.

Increasing the damage of the damage dealer is the natural thing to do.

Mighty Thor

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Mighty Thor is the only Hero Asgardian who is really dependent on Skirmisher Class. She needs to place Blind, Disrupt, and flip enemy buffs to be fully effective therefore anything but SKirmisher is a bad idea. Most importantly, her free attacks can place Trauma on enemies so making sure that enemies will not resist while placing free Vulnerability for Strikers in the team is something that is mandatory.

In short, anything but Skirmisher will be a mistake!

Valkyrie

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Valkyrie is a Brawler who has only 1 important debuff that cannot be placed at the start of combat. Therefore, there is really no need to give her anything but Striker ISO-8 Class.

Depending on the ISO-8 composition of other Hero Asgardians, Raider Class can also be useful for Valkyrie on some occasions. However, the best combo is to give Thor Raider class and exploit the Weakness debuff with Vakyrie's Striker class.

The last option, which I wouldn't suggest unless in Raids, is to emphasize Valkyrie's self-restoration with the Healer class. That would increase Hero Asgardian sustenance overall, and probably prolong fights. However, the main strength of Hero Asgardians is not their durability but for their offensive potential, therefore Striker class should be a priority as long as there is someone in the team to place Vulnerability.

Wong

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Wong is a Protector but his mechanics don't need additional sustenance from ISO-8 class to reach his full potential. Instead, he needs to be equipped with the Skirmisher class (like the rest of the Darkhold members) for his utility to be fully effective.

It's important to say that he will retaliate against any received attack by any of the Darkhold members. This means that he could also benefit from the Striker class if you want to increase the team's overall damage output.

In the end, if you still want to increase the sustenance of the Darkhold main Protector be sure to give him Fortifier which will only be effective if it is given to all other members as well. That way, the Darkhold's Barrier will be at least 30% stronger making them almost impenetrable.

Keep in mind that this decision will have a serious impact on the team's ability to efficiently place debuffs and use utilities.

Star-Lord [T'Challa]

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

T'Challa should be equipped with either the Skirmisher or the Striker ISO-8 class.

Make a decision depending on the class setup of the rest of the Ravager team. Since it is highly unlikely that anyone else will be equipped with Skirmisher, it would be best to give it to him.

Nevertheless, if Yondu has Skirmisher then equip T'Challa with the Striker class.

Spider-Punk

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Spider-Punk is a pure damage dealer, unlike all other Spiders.

The best Class for him is the Raider class, but he can benefit from the Striker class as well. Giving him a Skirmisher class can be justified only if he is a part of the full Skirmisher setup in DD.

Sersi

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Choose Sersi's ISO-8 class depending on Ikaris' class.

If Ikaris is equipped with Raider or Striker, Sersi should use the Skirmisher class. If Ikaris has the Skirmisher class, Sersi should use the Striker class.

Scarlet Spider

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

The natural ISO-8 pick for Scarlet Spider is the Raider class.

All of his skills hit multiple targets and he is ideal for the role of mass Vulnerability placer with an increased critical chance. However, if you are gonna use Web-Warriors in DD, it might be best to equip all members of the team with the Skirmisher class.

Giving Skirmisher to the entire team proved to be the most efficient setup for DD4 and DD5 in my experience.

Morgan Le Fay

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To make sure she will place Ability Block and Trauma to all Controllers at the start of combat Morgan must be equipped with the Skirmisher class. Additionally, that will help Darkhold to remove enemies' positive effects more efficiently (lack of remove-buffs abilities is the only slight weakness of the Darkhold team).

The other option is to boost the already incredible Barrier potential by giving Morgan the Fortifier class. This may seem like an awkward decision but it will grant amazing results in certain battles.

Morbius

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

The Skirmisher ISO-8 class is definitely the best option for Morbius. It grants full efficiency of his debuffs and helps remove positive effects from enemies. That is something that the Dark-Hunter team lacks.

There's also an option to give him the Raider and the Healer class but the benefits of those decisions are considerably lower than the Skirmisher option.

Magik

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

According to her skillset, the obvious choice for Magik is the Striker ISO-8 class. However, the team composition of Uncanny X-Man suggests that only Storm is able to place Vulnerability, therefore it might be better to equip Magik with Skirmisher.

In that case, Magik's utility is fully efficient and she removes all positive effects from the targets with each basic attack.

There is also a possibility to emphasize her powerful Barrier by giving her the Fortifier ISO-8 class.

Madelyne Pryor

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Madelyne Pryor needs the Skirmisher class to maximize the effectiveness of her utility and debuffs.

Since her main role in the Marauder team is to be a primary damage dealer she can also benefit from the Striker class. If she is equipped with the Striker, there should be at least two allies with Raider or Skirmisher (Stryfe and Mystique).

All in all, the Skirmisher class is a safe and obvious pick while Striker can be devastating in the right circumstances.

Kate Bishop

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Kate Bishop benefits the most from the Skirmisher class.

Her usefulness depends on the efficiency of her utility. She has no passive increase in Focus, so the Skirmisher class is an obvious decision.

However, players who wanna increase her damage and exploit the fact that she can hit multiple enemies with two of her skills, may choose the Raider class instead.

Ikaris

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Ikaris needs the Raider class to be fully effective.

As a pure damage dealer whose utility always hits, Ikaris doesn't have much benefit from Skirmisher.

Two of his abilities hits multiple targets and I find it hard to believe that the Striker class will give Ikaris better damage potential than the Raider class.

Ghost-Spider

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Unlike other members of the Web-Warrior team, Ghost-Spider's primary role is not to place debuffs. Instead, she is the main damage dealer.

She benefits from Skirmisher since it affects her ability to spread negative effects and place Ability Block and Blind.

In my opinion, the Raider class is better for her. Raider class makes Ability Block land on affected targets. Also, it will keep all enemies under Vulnerability during the entire fight.

Echo

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Echo should be equipped with either the Striker or Raider ISO-8 class.

She has no utility whatsoever so improving her damage output is the only viable solution. If you go after the Striker class be sure that there are enough Vulnerability placers in the Young Avenger team.

Dormammu

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Dormammu has two options for choosing ISO-8 class.

He needs Skirmisher top be sure that all his utilities are placed on targets. His basic Focus is amazing so on most occasions he won't need an extra Focus buff from the Skirmisher class. However, for fighting against MSF's current Meta he might need it.

The other obvious option is to give him the Raider class. All his skills cause unbelievable damage against multiple targets, so increasing his Critical Chance and placing mass Vulnerability with each attack seems to be the right thing to do.

Make the decision according to the class setup of Dormammu's allies.

Doctor Voodoo

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Doctor Voodoo can use the Skirmisher or the Healer ISO-8 class.

Skirmisher grants his special full effectiveness and place Ability Block and Defense Down always. Since he has no passive increase in Focus he must be boosted with Skirmisher, especially in War.

If Doctor Voodoo is used outside of war for PVE content it might be better to emphasize his healing with the Healer class.

Doctor Strange [Heartless]

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

In my opinion, all Darkhold Members should be equipped with Skirmisher class. This proved to be the most effective setup against enemy Darkhold.

However, DS Heartless' main role is to cause damage and place Slow with his special always (he has 500% increased Focus for that skill).

Some people will find using Skirmisher for him useless. Even though DS Heartless can truly cause immense damage with the Striker or Raider class, I suggest using Skirmisher because that is the only guarantee that his basic attack will flip enemy buffs into negative effects.

Agatha Harkness

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

I have a strong belief that all Darkhold members should be equipped with the Skirmisher class. There are two reasons for that.

The first reason is to make sure that all debuffs are placed and all utilities are effective.

The second reason is that the only possible weakness of Darkhold is the lack of options to continuously remove multiple positive effects from enemies.

However, there can be another way of thinking - the main strength of Darkhold, in general, is its impenetrable Barrier. Improving it should make them even more immune to anything.

Spider-Woman

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Outside of War Offense Spider-Woman needs Skirmisher to be fully effective.

In War Offense, she should be equipped with the Striker class to maximize her amazing damage potential. If there are lack of Vulnerability placers in the A-force team, even the Raider class can be an option since her special affect multiple targets.

Nico Minoru

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★

Iso-8

Nico Minoru can be extremely dangerous if all her utility finds its target. The safest way to make this happen is to give Skirmisher to Nico.

If you think that Nico's damage needs an increase, it's best to choose the Raider class over the Striker, because Nico has two AOE skills.

Gambit

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

All Gambit's abilities attack multiple targets so giving him the Raider class is the way to go.

Whenever he places a critical hit an Unlimited X-Men ally is buffed with Evade, so increasing his Critical Chance is always a priority. However, he may need benefits from the Skirmisher class to effectively exploit his utilities.

Make the decision depending on the class setup of the rest of the team. If there are enough allies who can place Vulnerability then it might be better to go with Skirmisher. If not use the Raider.

Fantomex

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Fantomex can benefit from three classes evenly - Skirmisher, Striker, and Fortifier.

To place debuffs and Taunt and remove buffs from enemies pick the Skirmisher. To maximize damage output pick the Striker. To improve Fantomex sustenance and boost up the barrier gained from Dazzler pick the Fortifier.

It may be appealing to give the Raider class to Fantomex since he will place Def Down with every critical hit using basic attack but in my opinion that would be a major mistake. Fantomex's critical chance is increased by Gambit's passive. Losing benefits from other classes is not justified just for increasing the Def Down chance, especially since all of his attacks are single-target based.

Dazzler

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Two of Dazzler's abilities are Single-target based, therefore giving her the Skirmisher class seems to be a logical choice.

However, since her Focus in Crucible grants debuffs placing, it might be best to give her the Raider class. Her ultimate affects all enemies and with every critical in CC, she will place Blind while using a basic attack.

It is important to say that she has an increased critical chance from Gambit's passive so you need to carefully consider what is the best choice. Even the Fortifier class is a viable option for Dazzler in Cosmic Crucible.

Omega Red

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Even though Omega Red's Focus is significantly increased in AW, I suggest equipping Skirmisher class just to be sure that his debuffs are landing. The other reason is that the Weapon-X team has no viable cleanser and Skirmisher grants constant cleansing.

If you put Skirmisher on Sabretooth, for example, it is not necessary to put it on Omega Red as well. In that case, you could emphasize the healing of the team with the Healer class.

Lady Deathstrike

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Lady Deathstrike’s main purpose is to be part of a sure-to-win AW team where she has permanently increased Focus, so Skirmisher class is not mandatory. In my opinion, the best Iso-8 class for her is Raider because she has two AOE attacks and increased Critical damage.

Outside of AW, the Skirmisher class is definitely better.

Silver Samurai

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Fortifier class is an obvious solution for Silver Samurai because you want to emphasize his already enormous Barrier.

He assists and Counters a lot and his attacks can be deadly, so ISO-8 Striker Class is another solution.

Even Skirmisher Class can be used if you wanna exploit his assist to remove buffs from enemies.

Deathpool

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

There is only one acceptable Iso-8 class for Deathpool and that is definitely Striker. Her already amazing damage is increased further so there is no doubt about it.

Someone could argue she benefits more from increased Crit Strike from the Raider class, but that is a mistake in my opinion. Having two team members (Cloak/Dagger) who place Vulnerability outside of ISO-8 class makes the choice even easier.

Cloak

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Skirmisher Class is the only logical option for Cloak.

Someone would say that he already has increased Focus but in the end game, every additional percent of Focus is much needed. He always assists Dagger on basic attacks so the urge for Skirmisher, placing Vulnerability and cleansing positive effects is even greater.

Dagger

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Same as for Cloak, Skirmisher Class brings most benefits to Dagger.

She already has an ability that clears enemy positive effects in "AOE"-ish way (it Chains). Since it's not beneficial for both of them to have Skirmisher (both of them apply Vulnerability) it might be best to equip her with Striker or Healer.

I am not a big fan of Healer class or Regeneration buffs but if someone is already placing Regeneration it might be best to emphasize the healing with more Regenerations.

Depending on the rest of the team, the Striker class could significantly increase the damage output of Dagger and her team.

Shang Chi

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Shang Chi's class can be Raider or Striker depending on other classes in the H4H. However, Striker class will make him do amazing damage so make sure you have enough Vulnerability placers in other H4H members.

Just be sure not to put him in the Healer or Skirmisher class.

Sharon Carter

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Choosing ISO-8 class for Sharon depends on other members of her team.

If an ally has Skirmisher class then she should go with Striker or Raider. If not then she should use Skirmisher class regardless of her Focus already maximized by other skills.

Maria Hill

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Healer ISO-8 class is the only viable solution for Maria Hill.

You can experiment with other classes, but honestly only the Healer class is a viable option for her.

Captain America [Sam Wilson]

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Choosing ISO-8 Class for Sam Wilson is tricky because he benefits from all classes.

The safest choice is to put him in the Fortifier or the Healer class depending on circumstances. On some occasions, you can use Sam Wilson as support with every other Class.

In short, whatever you choose, you won't make mistake.

Adam Warlock

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

In my opinion, the only viable solution for Adam Warlock is Skirmisher class.

You want him to place his Ability Blocks and Stuns always. However, there is another solution. You can equip him with Healer Class as an addition to Moondragon’s Healer and make Infinity Watch even tougher.

Moondragon

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

When we talk about ISO-8 class the logical solution is to equip Moondragon with Healer class.

However, there are other strategies as well as long as she is not equipped with Skirmisher class. She already has all virtues Skirmisher offers – she cleanses and she has increased focus.

Phyla-Vell

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Striker ISO-8 class is a natural decision for Phyla-Vell. You have one of the highest damage potentials and you want to increase it further.

However, since she assists a lot she may benefit from Skirmisher as well if you want to help your team with constant Offense Down and removing buff on enemies.

Doctor Doom

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

In my opinion, the Striker ISO-8 class is the only viable option for Doctor Doom. You want him to do additional attacks whenever possible.

However, since he has an AOE attack, the Raider class is also acceptable.

Kestrel

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Choosing between Striker or Raider Iso-8 class is a tough choice. Kestrel benefits the same from extra damage or extra critical.

Even the Skirmisher class is very appealing since Kestrel will have a lot of free attacks. This means she's able to place vulnerability and remove positive effects more often.

Jubilee

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Skirmisher is the only viable option for Jubilee because extra focus granted from Skirmisher is essential for Jubilee.

She has an AOE attack so she may benefit from Raider as well, but Skirmisher is the primary option always.

Colleen Wing

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Colleen can be developed in two directions depending on the classes of the rest of H4H team.

If there are enough Skirmishers in the team then she should be developed as a Striker. If you have other ideas you can use her as Skirmisher to place Bleeds on enemies.

Misty Knight

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

It would be logical to develop Misty as Skirmisher. All her attacks are single-target based.

However, since she's primarily used in War Defense with maximized Focus for all abilities it would be wise to give her Striker class. Let Colleen place Vulnerability with her constant assists and counterattacks.

Bishop

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Bishop can benefit from both Fortifier and Striker classes depending on how you want to use him.

I suggest that you use him as a pure damage dealer in Raids because Astonishing X-Men utility will give him enough protection. He only needs to kill enemies faster.

However, if you want to use Bishop in other MSF segments it's smart to offer him more protection because many teams in Alliance War and Real-Time Arena can easily overcome Astonishing’s utility making Bishop vulnerable.

Ghost

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Ghost can literally use any ISO-8 class because he does everything.

If you put him Skirmisher he will place Vulnerability to anyone who attacks him. If you chose the Healer class, his healing will be greater. If you give him Fortifier class, he will become untouchable.

Everything is up to you and your desires.

Stature

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Besides Fortifier ISO-8 class, Stature can successfully use the Skirmisher class.

She needs extra focus for flipping Defense Up on enemies. Since she can attack while placing Taunt, it is very useful to equip her with the ability to place Vulnerability with each strike.

Yellowjacket

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As a damage dealer, who has dual strike and AOE attack in his skill-set, Yellowjacket benefits from Striker, Skirmisher, or Raider ISO-8 class, depending on circumstances.

Be prepared to change his class often.

Anti-Venom

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

The most optimal setup for all members of original Symbiots is all-in on Skirmisher, even Anti-Venom. That is the only way for them to have decent cleansing potential. It is especially important in Dark Dimension and Raids.

However, on some occasions, Anti-Venom could benefit from Healer Class (if cleansing is not important and the team lacks sustain).

Scream

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Skirmisher class is always the first option for Scream because it is essential for Symbiots. They lack cleansing.

Scream's base damage potential is significantly higher than other Symbiots, so sometimes is wise to equip her with Strike class.

Additional damage from Striker can be the difference between a win and loss on some City nodes in DD.

Shatterstar

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Like Longshot, Shatterstar definitely needs Raider ISO-8 class for reaching his full potential.

His ability Set Up is built on Critical Hit so anything else but increasing it even further isn't as good choice.

She-Hulk

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

She-Hulk is a Protector and it's normal to develop her in Fortifier ISO-8 class.

However, in my opinion, the F4 would benefit more from Striker Class if there is at least one Skirmisher in the rest of the team.

With the introduction of GAMMA team, the ISO-8 role of She-Hulk doesn't change much. Her passive ability will be executed with increased Focus therefore she doesn't need Skirmisher. As someone who will have additional passive attacks, it is definitely the best to give her the Striker class. However, you must be careful that there are at least 1 raider and 1 Skirmisher in the rest of the GAMMA team.

Doctor Octopus

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Doctor Octopus can increase his healing even further if he is equipped with Healer Class. This is definitely the best class for him.

He can be equipped with the Raider class as well since he can exploit his AOE ultimate attack to place Vulnerability on multiple targets.

Swarm

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Swarm with either Raider or Striker class depending on the placement of other ISO-8 classes.

If there are enough Skirmishers use Striker class, otherwise, use Raider class.

Electro

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Electro should be equipped with either Raider ISO-8 Clar or Striker class depending on the team composition.

If there are enough skirmishers use Striker class, otherwise, use Raider class.

Baron Zemo

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Baron Zemo benefits the most from the Raider ISO-8 class.

Raider increases his Critical chance and allows him to place Vulnerability on multiple enemies after using his ultimate and his passive.

Beast

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Obviously, Beast should be equipped with a Healer ISO-8 class.

If for some reason you don't need any more healing you can equip him with Raider class to materialize his special AOE ability.

Squirrel Girl

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

The Healer ISO-8 class is a natural decision for this hero.

The other option is to increase Squirrel Girl's Focus and maximize her ultimate by equipping the Skirmisher class.

Emma Frost

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

To increase the already high sustenance of the Marauder team Emma Frost needs a Healer ISO-8 class.

You can also equip her with a Fortifier class and protect her against initial attacks but that shouldn't be the first option.

X-23

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

All her attacks are single-target based so her team will benefit the most with Skirmisher ISO-8 class.

Skirmisher clears positive effects from the target that is attacked by X-23's ultimate because with her ultimate X-23 strikes the target several times and each time she have a chance to place vulnerability. If the Vulnerability is placed on the target that already has Vulnerability, one positive effect is removed instead.

Yelena Belova

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

It is questionable whether Raider or Skirmisher class is better for Yelena.

With Raider class, she can exploit increased damage of Critical hits more often.

With Skirmisher class she is able to constantly place Vulnerability and you won't worry if she steals buffs or not, because her Focus is significantly increased.

Negasonic

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To increase Negasonic's Attack even further she needs Striker ISO-8 class.

Her ultimate opens the combat with striking all enemies so it may be better to equip her with Raider ISO-8 class. It will allow her to place Vulnerability on multiple enemies and to cause Critical Strikes more often.

Domino

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Domino with either the Raider ISO-8 class or the Skirmisher class, depending on the rest of the team.

It is important to mention that Skirmisher makes her Disrupt land on Mercenary Riot Guard, and that's crucial for countering Mercenary Team in AW Offense.

Ebony Maw

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

You can equip Ebony Maw with almost any ISO-8 class but in my opinion, he benefits the most from the Skirmisher class.

It increases his focus allowing him to always place Offense Down and Slow.

Giving him a Radier ISO-8 class is also smart since his ultimate hit all targets several times. That means he will place Vulnerability on all enemies after using ultimate.

However, majority of players give him the Healer class and that shouldn't be overlooked.

Cull Obsidian

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Cull Obsidian retaliates whenever someone attacks a Black Order ally so it's best to equip him with Skirmisher ISO-8 class. That let's him place Vulnerability on the entire enemy team very fast clearing positive effect in the process.

The other option in my opinion is Striker. It increases the overall damage output of BO.

Don't forget though that majority of players equip him with Fortifier instead.

Taskmaster

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Taskmaster with either Striker or Raider ISO-8 class depending on his team composition.

With recent improvements, Taskmaster will place his debuffs and utilities almost always regardless of enemy Resistance and his Focus. Even though he will assist in every Underworld turn, giving him Skirmisher Class could not be justified.

In my Underworld team, Taskmaster will be equipped with the Raider Class.

Corvus Glaive

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Depending on the rest of BO, equip Corvus with either Striker or Raider ISO-8 class.

He has no utility whatsoever, so going with Skirmisher doesn't look like an option. However, in my opinion, having 3 BO characters with the Skirmisher class is very effective.

Proxima Midnight

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Equip Proxima Midnight with either Raider or Striker ISO-8 class, depending what you give to Corvus Glaive.

If Corvus has the Striker class then Proxima needs Raider and vice-versa. Having three BO characters with Skirmisher class is also a viable option, especially for Proxima whose Offense Down debuff is crucial in some moments.

Red Skull

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since he's a summoner who attacks a single target with both of his offensive skills there are three options for Red Skull.

You can equip him with Striker class to maximize his attacking abilities or Skirmisher class to help his team with Vulnerability.

Another viable option is to give him a Healer class and further increase the sustenance of the Hydra team.

Whatever you chose you will not be mistaken.

Jessica Jones

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

After becoming part of the A-Force team, the best class for Jessica is definitely Striker.

Nevertheless, she is one of those characters that benefits from all classes evenly.

Mister Sinister

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Healer ISO-8 class is definitely the best for Mister Sinister. Equipping him with any other class is a no-go in any category.

Mystique

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Mystique with either Raider or Skirmisher ISO-8 class depending on the situation. Raider class is a priority though.

Juggernaut

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Juggernaut's main strength is his ultimate so increasing its power with Striker is an obvious decision.

Before, Juggernaut's sustenance was enough so the Fortifier wasn't mandatory. However, with the shrinking of BoM's actual strength there's a need for additional protection now. This makes Fortifier the first choice for Juggernaut.

Agent Coulson

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Agent Coulson attacks all enemies with two of his skills so equip him with the Raider ISO-8 class. That will place Vulnerability on multiple opponents and will increase his damage.

America Chavez

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As a single-target damage dealer America Chavez and her team will benefit the most if you equip her with Skirmisher ISO-8 class.

The other option is to simply improve her damage with Striker ISO-8 class.

Ant-Man

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Ant-Man with Raider ISO-8 class because he can open the battle with an AOE and place Vulnerability on multiple opponents.

If his main role is to place Abi Block and benefit from his utility, the Skirmisher class is definitely a better option.

Black Bolt

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Black Bolt needs a Striker ISO-8 class to further increase his unbelievable damage potential.

You can also equip him with Raider class but since he can't use his AOE early in the battle, it's better to let other allies place Vulnerability. This way he can unleash his increased damage.

Black Panther

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Black Panther with Striker ISO-8 class to reach his full potential.

Raider class is also an option if there's a lack of Vulnerability placers in the Wakanda team.

Black Widow

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Black Widow with the Skirmisher ISO-8 class to make sure that her debuffs and buff-steals are effective.

Blob

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As someone who can retaliate against every attack Blob needs Raider ISO-8 class to place Vulnerability as often as possible and increase his AOE damage with critical strikes.

Bullseye

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As a pure damage dealer, Bullseye needs a Striker ISO-8 class to reach his full potential. All other options are not good enough.

Cable

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Cable with Striker ISO-8 class. The Raider class could also be good for him. Make decision according to the Class setup of the rest of the allies.

Captain America

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Captain America needs to stay alive as much as possible so go with either Fortifier ISO-8 class to increase his survivability or Healer class to increase the overall sustenance of the entire team.

Captain Marvel

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Obviously, Captain Marvel needs a Striker ISO-8 class to further increase her incredible damage potential.

Carnage

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To increase his focus and chance of placing Bleed, Carnage needs the Skirmisher ISO-8 class. That will allow him to place Vulnerability and remove enemy buffs as well.

Colossus

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To increase his survivability Colossus needs a Fortifier ISO-8 class.

Since he can retaliate there is also an option to equip him with a Skirmisher class even though he is a protector.

Crossbones

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Equip Crossbones with Raider ISO-8 class to maximize the potential damage output of his ultimate.

Crystal

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since Crystal has 2 AOE abilities she should be equipped with Raider ISO-8 class which will allow her to place Vulnerability on the entire enemy team while increasing her damage potential in the process.

Cyclops

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Cyclops should be equipped either with Raider ISO-8 class or with Striker class depending on other existing classes in your X-Man team.

Daredevil

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Daredevil can be further improved if he is equipped with the Raider class which will allow him to initiate a fight with mass Vulnerability on the enemy team. If he is surrounded by characters who can place Vulnerability he could be equipped with Striker class as well.

Phoenix

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Choosing ISO-8 class for Phoenix can be tricky since buffs or debuffs activated by her can only be used by Phoenix and will not be available when she is reborn as Dark Phoenix. However, improved stats will remain after being reborn so increasing critical chance or damage is the best course of action. Improving Phoenix's sustenance will not be a wise choice because she is needed as Dark Phoenix as soon as possible. Having that in mind it is best to equip her with Striker class to improve her base damage potential. Raider class is another option that should be used only if you don't expect her to place Vulnerability.

Deadpool

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Depending on the placement of ISO-8 classes on other X-Force Heroes, Deadpool should be equipped with either Striker or Raider ISO-8 class.

Doctor Strange

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Doctor Strange should be equipped with either Healer or Skirmisher ISO-8 class depending on the needs of his current team.

Drax

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since he is a pure tank whose purpose is to survive as long as possible, the only logical course of action is to equip him with the Fortifier ISO-8 class.

Elektra

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

All of Elektra's skills are single-target skills, therefore she should be equipped with Skirmisher ISO-8 for increased Focus and the ability to cleanse enemy buffs. If you want to increase her damage give her Striker class.

Elsa Bloodstone

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Obviously, Elsa's Critical Chance needs to be improved even further, therefore, she has to be equipped with Raider ISO-8 class

Falcon

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Falcon should be equipped with either Striker or Raider ISO-8 class depending on his team composition and deployment of classes for other Power Armor allies.

Gamora

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To increase her Critical chance even further Gamora has to be equipped with Raider ISO-8 class. As one of the most powerful hitters in the game, she obviously can benefit from the Striker class as well but my thinking is that every increased stat should be further increased if possible - Gamora has increased Critical Chance so the choice is obvious.

Ghost Rider

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Ghost Rider applies debuffs with all his skills which means that he needs as much Focus as possible to be effective. Having that in mind and since he retaliates whenever his ally dies it is best to equip him with Skirmisher ISO-8 Class to maximize the potency of his skills and exploit free attacks.

Graviton

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Graviton should be equipped with either Raider or Skirmisher class depending on the placement of other classes in his A.I.M. team.

Green Goblin

Arena ★ ★ ★ ★
Alliance War Offense★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Probably the best course of action is to equip Green Goblin with the Striker ISO-8 class but depending on your needs he could be equipped with Skirmisher or Raider class as well.

Groot

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Once a META, Groot slowly became obsolete for almost all segments of the game. However, he is still useful in Raids (especially for new players), therefore increasing his Healing abilities is the only logical thing to do. Besides the Healer ISO-8 class, I cannot justify any other decision for this character.

Hawkeye

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To increase the power of his basic attacks Hawkeye should be equipped with Raider ISO-8 class. However, if needed, he could be equipped with Skirmisher class as well, to make sure that debuffs from his ultimate will be placed on enemies.

Heimdall

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Heimdall should be equipped with Raider ISO-8 class. He has 2 AOE abilities and anything else but Raider is not justified. However, Heimdal is so slow so relying on him as someone who will place Vulnerability that can be exploited, is not a wise decision.

Hela

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

In my opinion, Hela benefits the most from the Raider ISO-8 class. However, she can also be equipped with Healer or Skirmisher class depending on the team composition.

Hulk

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★
Alliance War Defense★ ★ ★
Blitz/Real-Time Arena★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★

Iso-8

Hulk should be equipped with either Skirmisher (because he can retaliate often) or Raider ISO-8 Class.

More importantly, Hulk's role in the GAMMA team requires that he is someone who places Vulnerability that can be exploited by Strikers. In ideal conditions, Hulk should be equipped with the Raider class to maximize his damage potential. however, if the team has problems with removing enemy buffs, especially in PVE, Hulk needs Skirmisher. It is true that he doesn't need Focus at all, but with his constant removal of enemy buffs, he can really turn the tide in your favor.

The final decision should depend on the ISO-8 class distribution of the rest of the GAMMA team.

Human Torch

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Even though he has an AOE ultimate, Human Torch should be equipped with Striker ISO-8 class because he can't use his ultimate before the third turn of combat so the possibility to place Vulnerability with the Raider class before that is minimal.

Iceman

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

In my opinion, Iceman will benefit the most from Skirmisher Class. He will not need an extra Focus for placing Slow but since he can make bonus attacks on every enemy turn it might be best to equip him with a fully improved Skirmisher class. He can also benefit from Raider class since almost all his attacks are AOE but the gain is not as with Skirmisher which can remove positive effects in the process.

Invisible Woman

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Invisible Woman and her team will benefit the most if she is equipped with the Healer class. Nevertheless, she could be equipped with Skirmisher class as well since she retaliates a lot.

Iron Fist

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Iron Fist can choose between Healer ISO-8 class and Raider class depending on the circumstances. In AW Defense, the HEaler Class is the only viable option.

Iron Man

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★
Raid
Dark Dimension ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To further increase his Critical Chance, Iron Man needs to be equipped with Raider ISO-8 class.

Ironheart

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Like the majority of Power Armor Heroes, Ironheart also needs a Raider ISO-8 class to reach her full potential. However, the decision should be made according to the circumstances. Without Skirmisher it is unlikely that she will place Def Down often.

Karnak

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Depending on the situation Karnak should be equipped with either Raider or Skirmisher ISO-8 class.

Killmonger

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Killmonger must be equipped with Raider ISO-8 class because all his skills are significantly empowered after critical strikes. After boosting Wakanda members in the 6.1 Update, this team becomes META for Cosmic Crucible. Having that in mind it might be possible to think of some premade Class setups to counter heavy obstacles. Even in that scenario, I can't think of any other class suitable for Kilmonger except the Raider ISO-8 class.

Kingpin

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★
Alliance War Defense ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

With the recent improvements, it is mandatory that Kingpin is equipped with a Fortifier class. As long as he has Barrier all summons will be buffed with Speed Up and Offense up at the end of his turn. With that said, it is futile to look to any other ISO-8 class but the Fortifier class!

Kitty Pride

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As a protector who heavily relies on Focus to be effective in clearing buffs or placing debuffs, it would be best to equip Kitty with Skirmisher ISO-8 class. She could also use Healer or Fortifier class but that would bring much lesser benefits in my opinion.

Korath the Pursuer

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To make sure that Korath's debuffs will not be resisted, he should be equipped with the Skirmisher ISO-8 class which will allow him to place Vulnerability and cleanse enemy buffs.

Loki

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since he is extremely squishy, Loki could benefit from Fortifier ISO-8 class but if you want to make sure that he will place Defense Down every time he uses his ultimate, equip him with Skirmisher class.

Longshot

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Obviously, Longshot must be equipped with Raider ISO-8 Class because he needs every percent of critical chance he can get.

Luke Cage

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To reach his full potential Luke should be equipped with Fortifier ISO-8 class. There is also an option to equip him with Healer Class to emphasize H4H overall healing but since Luke is unbelievably slow and his Turns will be extremely rare, the team will not benefit much from the Healer Class.

Magneto

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since Magneto has 2 AOE abilities it is best to give him Raider ISO-8 class. Obviously, it is of utmost importance that he places Blind with his Ulti so the Skirmisher class seems to be needed more. However, Magneto's base Focus is really big and with a passive bonus, his debuffs will be applied almost always against enemies of equal power. Unfortunately, In fighting with stronger enemies, the Skirmisher class is mandatory for Magneto to be effective.

Mantis

Arena ★ ★ ★ ★
Alliance War Offense ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since she is a straightforward healer any additional healing available for her is most welcomed. Equipping her with the Healer ISO-8 class is a natural course of action.

M'Baku

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

In my opinion, M'baku already has enough survivability so any more will not benefit him much. I should equip him with either Striker or Healer ISO-8 class depending on the needs.

Minn-Erva

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

More healing is never a bad thing so equipping Minn-Erva with Healer ISO-8 class is only logical.

Mister Fantastic

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

I think that Mister Fantastic needs a Striker ISO-8 class to be fully effective. Skirmisher class could also bring some benefits, especially for being sure that his utilities will work in full.

Mordo

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Mordo should use either Raider or Skirmisher ISO-8 class depending on what you want to rely - on his debuffs and ability to cleanse or on the ability to place Vulnerability on multiple targets at the start of combat.

Moon Knight

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Moon Knight should be equipped with ISO-8 Class that will synergize with the ISO-8 of the rest of his team (mainly White Tiger). Depending on needs he should be equipped with either Striker, Raider, or Skirmisher Class and he will deliver everything that is needed in almost any situation.

Ms.Marvel

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Depending on what you are wanting to enhance, Ms. Mavel should use either Fortifier or Raider ISO-8 class.

Multiple Man

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

More than any other Protector, Multiple Man benefits the most from Fortifier ISO-8 Class. He could be equipped with Healer Class or with Striker class but Fortifier Class is literally meant for him.

Mysterio

Arena ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Skirmisher ISO-8 Class grants Mysterio that he will place his debuffs outside of WAR and successfully clear enemy buffs with his basic attacks. On the other hand, the Raider class allows him to initiate the fight with mass Vulnerability on enemies. It is up to you what you will choose, but I prefer the Raider class for Mysterio.

Namor

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Namor obviously needs Raider ISO-8 class to reach his full potential and to fully exploit his AOE ability in AW Offense.

Nebula

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Nebula became a META character with the release of Infinity Watch. While she is with Gamora, she will assist every attack meaning that the team can benefit from the Skirmisher class equipped with her. That would allow passive removing of enemy buffs during the entire fight. Since Nebula doesn't have any utility whatsoever she will not gain an advantage from increased Focus. That is why I prefer equipping her with Striker class trying to maximize the damage output of the Nebula/Gamora duo.

Nick Fury

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since Nick Fury grants additional energy with every critical strike of his basic attack it is logical to give him the Raider ISO-8 class. However, as he has only 1 attacking ability it might be better to equip him with the Healer class to increase the sustenance of his S.H.I.E.L.D. allies.

Night Nurse

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Like all straightforward healers, the Night Nurse needs the Healer ISO-8 class to improve her healing and survivability.

Nobu

Arena ★ ★ ★ ★
Alliance War Offense
Alliance War Defense ★ ★ ★ ★
Blitz/Real-Time Arena ★ ★
Raid ★ ★ ★
Dark Dimension ★ ★ ★
Cosmic Crucible ★ ★ ★

Iso-8

As a summoner who can only contribute to the team by summoning minions or buffing allies, Nobu should be equipped with Healer ISO-8 class which should make him at least somewhat useful.

Okoye

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Okoye gains Charged on every successful Critical hit (hers or any other Wakanda ally's) so the Raider class is an obvious choice. However, since the Raider class will be given to at least 2 other Wakanda allies, choosing Skirmisher for Okoye is also an option especially since it will be in synergy with her basic attack.

Polaris

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As someone who relies on Focus, it is logical that the Skirmisher class should be best for Polaris, but since she already has an unbelievable Focus it might be better to equip her with Raider class because all her attacks are AOE based.

Psylocke

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Depending on the placement of ISO-8 classes on other X-Men Heroes, Psylocke should be equipped with either Skirmisher or Striker ISO-8 class.

Punisher

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since Punisher opens the combat with an AOE it might be best to equip him with Raider ISO-8 class. However, it is questionable if the Raider class offers higher overall damage output than the Striker class.

Pyro

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Despite the fact that he already has increased Focus and that all his skills hit multiple targets, Pyro needs the Skirmisher ISO-8 class to be sure that he will place Disrupt when needed (on S.H.I.E.L.D. Security for example). It would be logical that he is given Raider class since he always strikes more than 1 target but his physical damage is so low that it is literally the same if he has a 100% Critical Chance or 0%.

Quake

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since Quake hits multiple targets with all her skills it might be best to equip her with the Raider ISO-8 Class. However, if you want to be sure that she will place Slow and Offense Down on every targeted enemy be sure to equip her with the Skirmisher class.

Red Guardian

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

It would be best that Red Guardian is either a full Healer or a full Attacker, therefore, he should be equipped with the Healer class or Striker class.

Rescue

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

The sole purpose of Rescue is to live long enough to cast her ultimate and empower her Power Armor ally. To make sure that she will be alive to that you should equip her with Fortifier ISO-8 class. However, if you are certain that she will not die, the Healer class will then provide more benefits for the team.

Rhino

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since Rhino causes serious damage with all his abilities, that advantage should be improved by giving him the Striker or Raider ISO-8 class.

Rocket Raccoon

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Rocket Raccoon should be equipped with either Raider or Striker ISO-8 class depending on your needs. Raider class suits him better obviously because almost all his attacks are AOE-based but since his base damage is really high, Strike class can also be put into good use.

Ronan the Accuser

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

If we follow logic, Ronan should be equipped with Raider ISO-8 class because he has an AOE that can be used in the second turn of combat, but if want to enhance his focus and make sure that he will cleanse all positive effects with the basic skill he should be equipped with Skirmisher class.

Sabretooth

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Since Sabretooth strikes multiple targets with 2 of his skills it is only logical to equip him with Raider ISO-8 class. However, if you want his Bleeds to be successfully placed on enemies while giving Weapon X a viable cleansing option, the Skirmisher class will do the trick. The decision should be made depending on Wolverine's class - if Wolverine has the Raider class Sabretooth should have Skirmisher, and vice-versa.

Scarlet Witch

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Deciding what ISO-8 class is best for Scarlet Witch can be kinda tricky because she can use Healer, Skirmisher, and Raider classes with the same success depending on the situation. As a part of Darkhold, the decision should be made depending on the other characters' Clas setup. However, in my opinion, the Skirmisher class should be a priority because in the end the best Darkhold team will the one who places all debuffs and removes most of the enemys' buffs.

Scientist Supreme

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Scientist Supreme is not a straightforward healer but her team will benefit the most if she is equipped with a Healer ISO-8 class. Her initial debuffs salvo will indeed be stronger with the Skirmisher class but in the even circumstances, she will be effective even without it.

Shocker

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Shocker needs all the additional damage he can get so he should be given a Striker ISO-8 class without a doubt.

Shuri

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

It is hard to justify any other class but the Healer class for Shuri. She has only 1 attacking ability that could be more effective with Skirmisher indeed, but there will not be many reasons for making that decision.

Silver Surfer

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Choosing a class for Silver Surfer depends on many circumstances. At first glance, his Skill-set requires the Skirmisher class to be fully effective. However, since Surfer's Focus can be dramatically increased if there is only 1 Cosmic Hero and since he lowers the Resistance of enemies as long as they are debuffed with Heal Block (he initiates every fight with it) other class options are also available to him. Giving him the Raider class is an obvious decision due to his AOE potential but it will not be a mistake to give him a Striker class as well. The funniest thing is that giving SS the Healer or the Fortifier class can be justified very often.

In short, I've accepted the fact that the continuous spending on ISO-8 Crystals is the only way of using Silver Surfer effectively.

Sif

Arena★ ★ ★ ★ ★
Alliance War Offense ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Since she is a Protector it would be obvious to equip her with Fortifier ISO-8 class, but since she counterattacks a lot it might be better to equip her with either Skirmisher or Raider class.

Spider-Man

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

In my opinion, Spider-Man needs Raider ISO-8 class. However, the Skirmisher class allows him to place his debuffs with 100% certainty. Be sure to choose the Skirmisher class if you are assembling the Web-Warrior team for DD City nodes.

Spider-Man [Miles]

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Similar to the original Spider-Man, I would equip Miles with Raider ISO-8 class but if you want to be sure that his debuffs will be placed equip him with Skirmisher class. It is important to say that if you will use this character for DD City Nodes, the Skirmisher class should be a priority for all members of the Web-Warrior team.

Spider-Man [Symbiote]

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Choosing ISO-8 for SSM depends on what you need. If you need damage primarily you should give him the Raider class. However, if you need Symbiots to be fully effective in DD, SSM needs the Skirmisher like all other members of the team.

Star-Lord

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Star-Lord should be equipped either with Skirmisher or Striker class depending on your needs and desires (if you want to maximize damage pick Striker; if you want that Blind is always placed and that he can remove enemys' buffs pick the Skirmisher). Even the Raider class can be a viable option due to his AOE basic attack.

Storm

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Since all of Storm's skills affects multiple targets it is only logical to equip her with Raider ISO-8 class. If you are using her in DD trying to build her charges and execute empowered Ulti against enemy waves, the Striker class is a better option.

Stryfe

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Despite the fact that he has serious damage potential, the only purpose of Stryfe is to avoid being killed. For doing that he obviously needs the Fortifier ISO-8 class.

Thanos

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Since he is a Protector it would be logical to equip him with Fortifier ISO-8 class, however when he gets his empowered status both Striker class and Skirmisher class are better for him. With Striker class, he has increased damage potential and with Skirmisher class no one can resist his special ability in the Empowered state. 

The Thing

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

If you want to exploit his retaliation abilities equip him with Skirmisher class but if you want to increase his damage output give him the Striker Class.

The Thor

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

He should be equipped with either Striker or Raider ISO-8 class. However, since he unleashes AOE attacks quite often it might be best to exploit that fact by giving him the Raider class.

Toad

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Toad should be equipped with either Skirmisher or Raider ISO-8 class depending on your BoM team composition and your desires.

Ultimus

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To make sure that he will always steal positive effects from the target Ultimus has to be equipped with Skirmisher ISO-8 class.

Ultron

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To make sure that Ultron will earn enough killing blows to maintain his ability energy flow be sure to equip him with Striker ISO-8 class and to combine him with Heroes who can place Vulnerability on enemies.

Venom

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Venom needs extra Focus to place his debuffs so equipping him with Skirmisher ISO-8 class is an obvious course of action.

Vision

Arena★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★
Raid★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Vision needs either Raider or Skirmisher ISO-8 class. The decision mainly depends on the needs of the rest of the Bionic Avengers.

Personally, I prefer Skirmisher to make sure that his Abi Block and his utility will be at full efficiency. However, utilities and debuffs are usually easily placed in Raids, therefore, if you are about to use Bionic Avengers only in Raids, Vision should have Raider ISO-8 class instead.

For having a viable attacking option in Bionic Avengers for AW and CC, placing Skirmisher on Vision is definitely a better option

Vulture

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

If you want to increase Vulture's chance of placing Slow with his special skill equip him with the Skirmisher ISO-8 class. If you want to exploit his AOE ability give him Raider ISO-8 class.

War Machine

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

War Machine has to be equipped with raider ISO-8 class. Everything else would be a mistake.

Wasp

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

Wasp should be equipped with either Striker or Raider ISO-8 class depending on your needs.

White Tiger

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

As a single target damage dealer who places negative effects with every ability, White Tiger will benefit the most from the Skirmisher Iso-8 class which will increase her Focus and allow her to clear positive effects from her enemies.

Winter Soldier

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★ ★
Raid ★ ★ ★ ★
Dark Dimension★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★ ★

Iso-8

To improve his already high critical chance he should be given a Raider ISO-8 class. However, he can benefit from Skirmisher and Striker classes as well, depending on the circumstances.

Wolverine

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Wolverine should be equipped with either Striker or Raider ISO-8 class depending on Weapon X, X-Men, or Brawler team class deployment.

Yondu

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Yondu needs Skirmisher to improve his focus and make sure that he will steal and clear positive effects on enemies. However, in War, he doesn't need any additional Focus, therefore, it is better to give him the Raider class and exploit his AOE.

Yo-Yo

Arena★ ★ ★ ★ ★
Alliance War Offense★ ★ ★ ★
Alliance War Defense★ ★ ★ ★ ★
Blitz/Real-Time Arena★ ★ ★ ★
Raid★ ★ ★ ★
Dark Dimension★ ★ ★ ★ ★
Cosmic Crucible★ ★ ★ ★

Iso-8

Yoyo is very squishy without his dodge and has to be alive as long as possible, therefore equipping him with Fortifier ISO-8 class is the only logical solution. However, if your Yo-Yo is strong enough you could try to exploit his AOE attacks by giving him Raider ISO-8 class.